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Electroencephalographic characteristics of epileptic seizures in preterm neonates

Janackova, S; Boyd, S; Yozawitz, E; Tsuchida, T; Lamblin, M-D; Gueden, S; Pressler, R; (2016) Electroencephalographic characteristics of epileptic seizures in preterm neonates. Clinical Neurophysiology , 127 (8) pp. 2721-2727. 10.1016/j.clinph.2016.05.006. Green open access

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Abstract

OBJECTIVE: Although seizures are more common in the neonatal period than in any other stage of childhood, those in preterm neonates are still poorly described. The aim of this study was to assess electro-clinical characteristics of seizures occurring before a corrected age of 40 weeks in neonates born prematurely. METHOD: Retrospective analysis of EEG-documented seizures in neonates born prematurely. Seizures in a group of term neonates served as controls. RESULTS: Fifty-six prematurely born and 46 term born neonates were included. Median duration of seizures was 52 s in preterm and 96 s in term neonates. Seizures were focal or multifocal. In least mature neonates, they involved smaller regions of onset and remained localised. With increasing corrected age, propagation became more frequent. The electrographic pattern – maximal frequency of oscillation and the onset pattern also evolved with age. Electro-clinical seizures were observed in 25% of preterm versus 50% of term neonates; almost all electro-clinical seizures involved the central (motor) regions. CONCLUSION: Ictal EEG features undergo changes depending on corrected age. Most seizures are subclinical, thus EEG is essential for diagnosis. SIGNIFICANCE: Relating ictal EEG pattern to corrected age can improve diagnosis and ultimately management.

Type: Article
Title: Electroencephalographic characteristics of epileptic seizures in preterm neonates
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.clinph.2016.05.006
Publisher version: http://doi.org/10.1016/j.clinph.2016.05.006
Language: English
Additional information: © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher.
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Preterm, Neonate, Epileptic seizures, Electroencephalography, HYPOXIC-ISCHEMIC ENCEPHALOPATHY, ELECTROGRAPHIC SEIZURES, HUMAN-BRAIN, EEG, INFANTS, RECEPTORS, PATTERNS, RISK, CONSEQUENCES, HIPPOCAMPUS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1504310
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