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Cellular Contraction and Polarization Drive Collective Cellular Motion

Notbohm, J; Banerjee, S; Utuje, KJ; Gweon, B; Jang, H; Park, Y; Shin, J; ... Marchetti, MC; + view all (2016) Cellular Contraction and Polarization Drive Collective Cellular Motion. Biophysical Journal , 110 (12) pp. 2729-2738. 10.1016/j.bpj.2016.05.019. Green open access

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Abstract

Coordinated motions of close-packed multicellular systems typically generate cooperative packs, swirls, and clusters. These cooperative motions are driven by active cellular forces, but the physical nature of these forces and how they generate collective cellular motion remain poorly understood. Here, we study forces and motions in a confined epithelial monolayer and make two experimental observations: 1) the direction of local cellular motion deviates systematically from the direction of the local traction exerted by each cell upon its substrate; and 2) oscillating waves of cellular motion arise spontaneously. Based on these observations, we propose a theory that connects forces and motions using two internal state variables, one of which generates an effective cellular polarization, and the other, through contractile forces, an effective cellular inertia. In agreement with theoretical predictions, drugs that inhibit contractility reduce both the cellular effective elastic modulus and the frequency of oscillations. Together, theory and experiment provide evidence suggesting that collective cellular motion is driven by at least two internal variables that serve to sustain waves and to polarize local cellular traction in a direction that deviates systematically from local cellular velocity.

Type: Article
Title: Cellular Contraction and Polarization Drive Collective Cellular Motion
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bpj.2016.05.019
Publisher version: http://doi.org/10.1016/j.bpj.2016.05.019
Language: English
Additional information: Copyright © 2016 Elsevier Ltd. All rights reserved. This is an Open Access article made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1503792
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