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1,135 Genomes Reveal the Global Pattern of Polymorphism in Arabidopsis thaliana

The 1001 Genomes Consortium; (2016) 1,135 Genomes Reveal the Global Pattern of Polymorphism in Arabidopsis thaliana. Cell , 166 (2) pp. 481-491. 10.1016/j.cell.2016.05.063. Green open access

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Abstract

Arabidopsis thaliana serves as a model organism for the study of fundamental physiological, cellular, and molecular processes. It has also greatly advanced our understanding of intraspecific genome variation. We present a detailed map of variation in 1,135 highquality re-sequenced natural inbred lines representing the native Eurasian and North African range and recently colonized North America. We identify relict populations that continue to inhabit ancestral habitats, primarily in the Iberian Peninsula. They have mixed with a lineage that has spread to northern latitudes from an unknown glacial refugium and is now found in a much broader spectrum of habitats. Insights into the history of the species and the finescale distribution of genetic diversity provide the basis for full exploitation of A. thaliana natural variation through integration of genomes and epigenomes with molecular and non-molecular phenotypes.

Type: Article
Title: 1,135 Genomes Reveal the Global Pattern of Polymorphism in Arabidopsis thaliana
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cell.2016.05.063
Publisher version: http://dx.doi.org/10.1016/j.cell.2016.05.063
Language: English
Additional information: © 2016 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Keywords: Arabidopsis thaliana; 1001 Genomes; glacial refugia; GWAS; population expansion
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/1503762
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