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Palliative Medicines for Children – A New Frontier in Paediatric Research

Jamieson, EM; Wong, ICK; Craig, F; Christiansen, N; Brombley, K; Tuleu, C; Harrop, E; (2017) Palliative Medicines for Children – A New Frontier in Paediatric Research. Journal of Pharmacy and Pharmacology , 69 (4) pp. 377-383. 10.1111/jphp.12615. Green open access

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Abstract

Objectives: This paper seeks to highlight from a UK perspective the current lack of a research evidence base in paediatric palliative care that has resulted in a paucity of available medicines with appropriate formulations (strength and dosage form) to provide symptom management for children with life-limiting illnesses and to raise awareness of this group of “therapeutic orphans”. Currently, clinicians have limited, often unsuitable medication choices for their paediatric palliative care patients, with little hope of moving away from the status quo. / Key findings: Most medicines used in children receiving palliative care are old and off-patent drugs, developed for and tested in an adult population. Many are not available in suitable formulations (dosage form and strength) for administration to children and there are often no age-related profiles of adverse drug reactions or for safe dosing. / Summary: Existing regional paediatric palliative care networks and support organisations should lobby funding bodies and the academic community to support appropriate research for this group of therapeutic orphans. Support must also be provided to pharmaceutical companies in the development of suitable products with appropriate formulations.

Type: Article
Title: Palliative Medicines for Children – A New Frontier in Paediatric Research
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jphp.12615
Publisher version: http://dx.doi.org/10.1111/jphp.12615
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Medicines for children, paediatric palliative care, paediatric medicines, end of life care, symptom management, out of hospital care, hospice care, preferred place of care.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy
URI: https://discovery.ucl.ac.uk/id/eprint/1503563
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