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Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms

Gnudi, L; Coward, RJ; Long, DA; (2016) Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms. Trends in Endocrinology & Metabolism , 27 (11) pp. 820-830. 10.1016/j.tem.2016.07.002. Green open access

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Abstract

Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy (DN) are focussing on blood pressure control with inhibitors of the renin-angiotensin-aldosterone system, on glycaemic and lipid control, and life-style changes. In this review, we highlight new molecular insights aiding our understanding of the initiation and progression of DN, including glomerular insulin resistance, dysregulation of cellular substrate utilisation, podocyte-endothelial communication, and inhibition of tubular sodium coupled glucose reabsorption. We believe that these mechanisms offer new therapeutic targets that can be exploited to develop important renoprotective treatments for DN over the next decade.

Type: Article
Title: Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tem.2016.07.002
Publisher version: http://doi.org/10.1016/j.tem.2016.07.002
Language: English
Additional information: Crown Copyright © 2016 Published by Elsevier Ltd. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: SGLT2, diabetes, endothelium, glomerulus, oxidative stress, podocytes
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1503542
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