UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

Xiao, L; Ohayon, D; McKenzie, IA; Sinclair-Wilson, A; Wright, JL; Fudge, AD; Emery, B; ... Richardson, WD; + view all (2016) Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning. Nature Neuroscience , 19 (9) pp. 1210-1217. 10.1038/nn.4351. Green open access

[img]
Preview
Text
Xiao et al Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning AAM.pdf

Download (1MB) | Preview

Abstract

We identified mRNA encoding the ecto-enzyme Enpp6 as a marker of newly forming oligodendrocytes, and used Enpp6 in situ hybridization to track oligodendrocyte differentiation in adult mice as they learned a motor skill (running on a wheel with unevenly spaced rungs). Within just 2.5 h of exposure to the complex wheel, production of Enpp6-expressing immature oligodendrocytes was accelerated in subcortical white matter; within 4 h, it was accelerated in motor cortex. Conditional deletion of myelin regulatory factor (Myrf) in oligodendrocyte precursors blocked formation of new Enpp6+ oligodendrocytes and impaired learning within the same ~2−3 h time frame. This very early requirement for oligodendrocytes suggests a direct and active role in learning, closely linked to synaptic strengthening. Running performance of normal mice continued to improve over the following week accompanied by secondary waves of oligodendrocyte precursor proliferation and differentiation. We concluded that new oligodendrocytes contribute to both early and late stages of motor skill learning.

Type: Article
Title: Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nn.4351
Publisher version: http://dx.doi.org/10.1038/nn.4351
Language: English
Additional information: Copyright © 2016 Nature America, Inc. All rights reserved. The published version of record is available at http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4351.html
Keywords: motor learning, motor performance, skill learning, glia, oligodendrocyte, precursor cell, NG2 cell, myelin, white matter, mouse
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/1503504
Downloads since deposit
98Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item