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Mobility Experiments With Microrobots for Minimally Invasive Intraocular Surgery

Ullrich, F; Bergeles, C; Pokki, J; Ergeneman, O; Erni, S; Chatzipirpiridis, G; Pané, S; ... Nelson, BJ; + view all (2013) Mobility Experiments With Microrobots for Minimally Invasive Intraocular Surgery. Investigative Opthalmology & Visual Science , 54 (4) pp. 2853-2863. 10.1167/iovs.13-11825. Green open access

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Abstract

Purpose.: To investigate microrobots as an assistive tool for minimally invasive intraocular surgery and to demonstrate mobility and controllability inside the living rabbit eye. / Methods.: A system for wireless magnetic control of untethered microrobots was developed. Mobility and controllability of a microrobot are examined in different media, specifically vitreous, balanced salt solution (BSS), and silicone oil. This is demonstrated through ex vivo and in vivo animal experiments. / Results.: The developed electromagnetic system enables precise control of magnetic microrobots over a workspace that covers the posterior eye segment. The system allows for rotation and translation of the microrobot in different media (vitreous, BSS, silicone oil) inside the eye. / Conclusions.: Intravitreal introduction of untethered mobile microrobots can enable sutureless and precise ophthalmic procedures. Ex vivo and in vivo experiments demonstrate that microrobots can be manipulated inside the eye. Potential applications are targeted drug delivery for maculopathies such as AMD, intravenous deployment of anticoagulation agents for retinal vein occlusion (RVO), and mechanical applications, such as manipulation of epiretinal membrane peeling (ERM). The technology has the potential to reduce the invasiveness of ophthalmic surgery and assist in the treatment of a variety of ophthalmic diseases.

Type: Article
Title: Mobility Experiments With Microrobots for Minimally Invasive Intraocular Surgery
Open access status: An open access version is available from UCL Discovery
DOI: 10.1167/iovs.13-11825
Publisher version: http://dx.doi.org/10.1167/iovs.13-11825
Language: English
Additional information: Copyright © Association for Research in Vision and Ophthalmology 2013.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1503368
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