Moran, C;
Tapp, RJ;
Hughes, AD;
Magnussen, CG;
Blizzard, L;
Phan, TG;
Beare, R;
... Srikanth, V; + view all
(2016)
The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy.
Journal of Diabetes Research
, 2016
, Article 6328953. 10.1155/2016/6328953.
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Abstract
It is uncertain whether small vessel disease underlies the relationship between Type 2 Diabetes Mellitus (T2DM) and brain atrophy. We aimed to study whether retinal vascular architecture, as a proxy for cerebral small vessel disease, may modify or mediate the associations of T2DM with brain volumes. In this cross-sectional study using Magnetic Resonance Imaging (MRI) scans and retinal photographs in 451 people with and without T2DM, we measured brain volumes, geometric measures of retinal vascular architecture, clinical retinopathy, and MRI cerebrovascular lesions. There were 270 people with (mean age 67.3 years) and 181 without T2DM (mean age 72.9 years). T2DM was associated with lower gray matter volume (). T2DM was associated with greater arteriolar diameter () and optimality ratio (), but these associations were attenuated by adjustments for age and sex. Only optimality ratio was associated with lower gray matter volume (). The inclusion of retinal measures in regression models did not attenuate the association of T2DM with gray matter volume. The association of T2DM with lower gray matter volume was independent of retinal vascular architecture and clinical retinopathy. Retinal vascular measures or retinopathy may not be sufficiently sensitive to confirm a microvascular basis for T2DM-related brain atrophy.
| Type: | Article |
|---|---|
| Title: | The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1155/2016/6328953 |
| Publisher version: | http://doi.org/10.1155/2016/6328953 |
| Language: | English |
| Additional information: | Copyright © 2016 C. Moran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, Medicine, Research & Experimental, Research & Experimental Medicine, SMALL-VESSEL DISEASE, MICROVASCULAR ABNORMALITIES, COGNITIVE FUNCTION, ATHEROSCLEROSIS RISK, CARDIOVASCULAR RISK, ALZHEIMERS-DISEASE, BRAIN ATROPHY, FOLLOW-UP, DYSFUNCTION, DEMENTIA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1503327 |
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