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Tight junctions: from simple barriers to multifunctional molecular gates

Zihni, C; Mills, C; Matter, K; Balda, MS; (2016) Tight junctions: from simple barriers to multifunctional molecular gates. Nature Reviews Molecular Cell Biology , 17 (9) pp. 564-580. 10.1038/nrm.2016.80. Green open access

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Abstract

Epithelia and endothelia separate different tissue compartments and protect multicellular organisms from the outside world. This requires the formation of tight junctions, selective gates that control paracellular diffusion of ions and solutes. Tight junctions also form the border between the apical and basolateral plasma-membrane domains and are linked to the machinery that controls apicobasal polarization. Additionally, signalling networks that guide diverse cell behaviours and functions are connected to tight junctions, transmitting information to and from the cytoskeleton, nucleus and different cell adhesion complexes. Recent advances have broadened our understanding of the molecular architecture and cellular functions of tight junctions.

Type: Article
Title: Tight junctions: from simple barriers to multifunctional molecular gates
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nrm.2016.80
Publisher version: http://dx.doi.org/10.1038/nrm.2016.80
Language: English
Additional information: Copyright © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Keywords: Science & Technology, Life Sciences & Biomedicine, Cell Biology, Nucleotide Exchange Factor, Transepithelial Electrical-resistance, Paracellular Chloride Permeability, Transcription Factor Zonab/dbpa, Integral Membrane-proteins, Tube Size Control, Epithelial-cells, Adhesion Molecule, Claudin-2 Expression, Zonula Occludens
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1502767
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