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In vivo bioimpedance changes during haemorrhagic and ischaemic stroke in rats: Towards 3D stroke imaging using electrical impedance tomography

Dowrick, T; Blochet, C; Holder, D; (2016) In vivo bioimpedance changes during haemorrhagic and ischaemic stroke in rats: Towards 3D stroke imaging using electrical impedance tomography. Physiological Measurement , 37 (6) pp. 765-784. 10.1088/0967-3334/37/6/765. Green open access

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Abstract

Electrical impedance tomography (EIT) could be used as a portable non-invasive means to image the development of ischaemic stroke or haemorrhage. The purpose of this study was to examine if this was possible using time difference imaging, in the anesthetised rat using 40 spring-loaded scalp electrodes with applied constant currents of 50-150 μA at 2 kHz. Impedance changes in the largest 10% of electrode combinations were -12.8% ± 12.0% over the first 10 min for haemorrhage and +46.1% ± 37.2% over one hour for ischaemic stroke (mean ± SD, n = 7 in each group). The volume of the pathologies, assessed by tissue section and histology post-mortem, was 12.6 μl ± 17.6 μl and 12.6 μl ± 17.6 μl for haemorrhage and ischaemia respectively. In time difference EIT images, there was a correspondence with the pathology in 3/7 cases of haemorrhage and none of the ischaemic strokes. Although the net impedance changes were physiologically reasonable and consistent with expectations from the literature, it was disappointing that it was not possible to obtain reliable EIT images. The reason for this are not clear, but probably include confounding effects of secondary ischaemia for haemorrhage and tissue and cerebrospinal fluid shifts for the stroke model. With this method, it does not appear that EIT with scalp electrodes is yet ready for clinical use.

Type: Article
Title: In vivo bioimpedance changes during haemorrhagic and ischaemic stroke in rats: Towards 3D stroke imaging using electrical impedance tomography
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/0967-3334/37/6/765
Publisher version: http://dx.doi.org/10.1088/0967-3334/37/6/765
Language: English
Additional information: Copyright © 2016 Institute of Physics and Engineering in Medicine. Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (CC BY 3.0) (https://creativecommons.org/licenses/by/3.0/). Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
Keywords: electrical impedance tomography, stroke, haemorrhage, ischaemia, rat model
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1502566
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