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Coupling changes in cell shape to chromosome segregation

Ramkumar, N; Baum, B; (2016) Coupling changes in cell shape to chromosome segregation. Nature Reviews Molecular Cell Biology , 17 (8) pp. 511-521. 10.1038/nrm.2016.75. Green open access

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Abstract

Animal cells undergo dramatic changes in shape, mechanics and polarity as they progress through the different stages of cell division. These changes begin at mitotic entry, with cell–substrate adhesion remodelling, assembly of a cortical actomyosin network and osmotic swelling, which together enable cells to adopt a near spherical form even when growing in a crowded tissue environment. These shape changes, which probably aid spindle assembly and positioning, are then reversed at mitotic exit to restore the interphase cell morphology. Here, we discuss the dynamics, regulation and function of these processes, and how cell shape changes and sister chromatid segregation are coupled to ensure that the daughter cells generated through division receive their fair inheritance.

Type: Article
Title: Coupling changes in cell shape to chromosome segregation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nrm.2016.75
Publisher version: http://doi.org/10.1038/nrm.2016.75
Language: English
Additional information: Copyright © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. The final publication is available at Nature Reviews Molecular Cell Biology via http://dx.doi.org/10.1038/nrm.2016.75
Keywords: Science & Technology, Life Sciences & Biomedicine, Cell Biology, Mediated Abscission Checkpoint, Anaphase-Promoting Complex, Cleavage Furrow Formation, Mass Measurements Show, Mitotic Spindle, Aurora-B, Animal-Cells, Myosin-Ii, F-Actin, Drosophila Neuroblasts, Cell-Cycle Proteins, Cell Polarity, Mitosis, Myosin
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1502477
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