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On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype

Dey, G; Thattai, M; Baum, B; (2016) On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype. Trends in Cell Biology , 26 (7) pp. 476-485. 10.1016/j.tcb.2016.03.009. Green open access

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Abstract

If eukaryotes arose through a merger between archaea and bacteria, what did the first true eukaryotic cell look like? A major step toward an answer came with the discovery of Lokiarchaeum, an archaeon whose genome encodes small GTPases related to those used by eukaryotes to regulate membrane traffic. Although 'Loki' cells have yet to be seen, their existence has prompted the suggestion that the archaeal ancestor of eukaryotes engulfed the future mitochondrion by phagocytosis. We propose instead that the archaeal ancestor was a relatively simple cell, and that eukaryotic cellular organization arose as the result of a gradual transfer of bacterial genes and membranes driven by an ever-closer symbiotic partnership between a bacterium and an archaeon.

Type: Article
Title: On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tcb.2016.03.009
Publisher version: http://dx.doi.org/10.1016/j.tcb.2016.03.009
Language: English
Additional information: © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: GTPase, Lokiarchaeum, eukaryogenesis, evolution
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1502476
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