UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity

Watt, AJ; Cuntz, H; Mori, M; Nusser, Z; Sjostrom, PJ; Hausser, M; (2009) Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity. Nature Neuroscience , 12 (4) 463 - 473. 10.1038/nn.2285. Green open access

[img]
Preview
Text
Hausser_1378129_Traveling_waves_in_developing_cerebellar_cortex_ukmss-4248.pdf - Accepted version

Download (7MB) | Preview

Abstract

Correlated network activity is important in the development of many neural circuits. Purkinje cells are among the first neurons to populate the cerebellar cortex, where they sprout exuberant axon collaterals. We used multiple patch-clamp recordings targeted with two-photon microscopy to characterize monosynaptic connections between the Purkinje cells of juvenile mice. We found that Purkinje cell axon collaterals projected asymmetrically in the sagittal plane, directed away from the lobule apex. On the basis of our anatomical and physiological characterization of this connection, we constructed a network model that robustly generated waves of activity that traveled along chains of connected Purkinje cells. Consistent with the model, we observed traveling waves of activity in Purkinje cells in sagittal slices from young mice that require GABA(A) receptor-mediated transmission and intact Purkinje cell axon collaterals. These traveling waves are absent in adult mice, suggesting they have a developmental role in wiring the cerebellar cortical microcircuit.

Type: Article
Title: Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nn.2285
Publisher version: http://dx.doi.org/10.1038/nn.2285
Language: English
Keywords: Resurgent sodium current, axon collaterals, retinal waves, synapses, neurons, rat, circuits, oscillations, inhibition, plasticity
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/150241
Downloads since deposit
32Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item