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PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

Rivers, LE; Young, KM; Rizzi, M; Jamen, F; Psachoulia, K; Wade, A; Kessaris, N; (2008) PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nature Neuroscience , 11 (12) 1392 - 1401. 10.1038/nn.2220. Green open access

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Abstract

Platelet-derived growth factor a receptor (PDGFRA)/NG2-expressing glia are distributed throughout the adult CNS. They are descended from oligodendrocyte precursors (OLPs) in the perinatal CNS, but it is not clear whether they continue to generate myelinating oligodendrocytes or other differentiated cells during normal adult life. We followed the fates of adult OLPs in Pdgfra-creER(T2)/Rosa26-YFP double-transgenic mice and found that they generated many myelinating oligodendrocytes during adulthood; > 20% of all oligodendrocytes in the adult mouse corpus callosum were generated after 7 weeks of age, raising questions about the function of the late-myelinating axons. OLPs also produced some myelinating cells in the cortex, but the majority of adult-born cortical cells did not appear to myelinate. We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb.

Type: Article
Title: PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nn.2220
Publisher version: http://dx.doi.org/10.1038/nn.2220
Language: English
Keywords: RAT OPTIC-NERVE, PDGF-ALPHA-RECEPTOR, CNS WHITE-MATTER, PROGENITOR CELLS, SUBVENTRICULAR ZONE, PRECURSOR CELLS, STEM-CELLS, NG2-EXPRESSING CELLS, CORPUS-CALLOSUM, SPINAL-CORD
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/150174
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