Coathup, MJ;
Blunn, GW;
Campion, C;
Ho, CY;
Hing, KA;
(2016)
The effect of increased microporosity on bone formation within silicate-substituted scaffolds in an ovine posterolateral spinal fusion model.
Journal of Biomedical Materials Research Part B: Applied Biomaterials
10.1002/jbm.b.33614.
(In press).
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Abstract
This study compared the bone forming capacity of the same formulation of silicate-substituted bone graft substitute materials with different microporosity in an instrumented posterolateral spinal fusion ovine model. Materials with a strut porosity of (i) 22.5% (SiCaP) or (ii) 36.0% (SiCaP(+)) were packed along either side of the spine. Bone apposition rates, % new bone formation, % bone-implant contact, and % graft resorption were quantified at 8, 12, and 24 weeks post surgery. Computed Tomography (CT) was used to grade the formation of fusion bridges between vertebrae. Results showed no significant difference in bone apposition rates, % new bone formation, and % bone-implant contact when the two materials were compared. However, at 8 weeks, a significantly higher CT score was obtained in the SiCaP(+) group (0.83±0.17) when compared with the SiCaP group (0.17±0.17; p=0.027). Significantly less scaffold remained in the SiCaP(+) group at 12 weeks (p=0.018). Both SiCaP and SiCaP(+) formulations augmented bone formation. Increasing the strut porosity did not significantly increase bone formation however, at 8 weeks it promoted the formation of more highly mineralized bone resulting in a significantly higher CT score, suggesting the bone tissue formed was more mature.
Type: | Article |
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Title: | The effect of increased microporosity on bone formation within silicate-substituted scaffolds in an ovine posterolateral spinal fusion model |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1002/jbm.b.33614 |
Publisher version: | http://dx.doi.org/10.1002/jbm.b.33614 |
Language: | English |
Additional information: | Copyright © 2016 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Coathup, MJ; Blunn, GW; Campion, C; Ho, CY; Hing, KA; (2016) The effect of increased microporosity on bone formation within silicate-substituted scaffolds in an ovine posterolateral spinal fusion model. Journal of Biomedical Materials Research Part B: Applied Biomaterials, which has been published in final form at http://dx.doi.org/10.1002/jbm.b.33614. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | bone regeneration; posterolateral spinal fusion; osteoconduction; strut porosity; calcium phosphate; sheep model; bone substitute materials |
UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/1501576 |
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