UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The Oscillopathic Nature of Language Deficits in Autism: From Genes to Language Evolution

Benítez-Burraco, A; Murphy, E; (2016) The Oscillopathic Nature of Language Deficits in Autism: From Genes to Language Evolution. Frontiers in Human Neuroscience , 10 , Article 120. 10.3389/fnhum.2016.00120. Green open access

[img]
Preview
Text
fnhum-10-00120.pdf - Published version

Download (800kB) | Preview

Abstract

Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders involving a number of deficits to linguistic cognition. The gap between genetics and the pathophysiology of ASD remains open, in particular regarding its distinctive linguistic profile. The goal of this article is to attempt to bridge this gap, focusing on how the autistic brain processes language, particularly through the perspective of brain rhythms. Due to the phenomenon of pleiotropy, which may take some decades to overcome, we believe that studies of brain rhythms, which are not faced with problems of this scale, may constitute a more tractable route to interpreting language deficits in ASD and eventually other neurocognitive disorders. Building on recent attempts to link neural oscillations to certain computational primitives of language, we show that interpreting language deficits in ASD as oscillopathic traits is a potentially fruitful way to construct successful endophenotypes of this condition. Additionally, we will show that candidate genes for ASD are overrepresented among the genes that played a role in the evolution of language. These genes include (and are related to) genes involved in brain rhythmicity. We hope that the type of steps taken here will additionally lead to a better understanding of the comorbidity, heterogeneity, and variability of ASD, and may help achieve a better treatment of the affected populations.

Type: Article
Title: The Oscillopathic Nature of Language Deficits in Autism: From Genes to Language Evolution
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fnhum.2016.00120
Publisher version: http://dx.doi.org/10.3389/fnhum.2016.00120
Language: English
Additional information: © 2016 Benítez-Burraco and Murphy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1501120
Downloads since deposit
59Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item