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Photodynamic therapy in the management of actinic keratosis: Retrospective evaluation of outcome

Jerjes, W; Hamdoon, Z; Abdulkareem, AA; Hopper, C; (2017) Photodynamic therapy in the management of actinic keratosis: Retrospective evaluation of outcome. Photodiagnosis and Photodynamic Therapy , 17 pp. 200-204. 10.1016/j.pdpdt.2016.04.017. Green open access

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Abstract

INTRODUCTION: Photodynamic therapy (PDT) is a minimally invasive intervention used in the management of tissue disorders. In this retrospective study, a total of 62 patients with actinic keratosis (AKs) were treated with surface illumination PDT. Comparisons with the clinical features, rate of recurrence as well as malignant transformation and overall outcome were made. MATERIALS AND METHODS: The medical records of 62 consecutive patients who presented with suspicious skin lesions and diagnosed with AKs were examined. These patients with 178 AKs lesions were treated with surface illumination methyl aminolevulinate - photodynamic therapy (MAL-PDT). The 16% strength cream (MAL) was applied topically 3hours prior to tissue illumination. A single-channel 628nm diode laser was used for illumination and light was delivered at 100J/cm(2) per site. These patients were followed-up for a mean of 7.4 years. RESULTS: Eight recurrences were reported after the first round of MAL-PDT, and two recurrences after the second round. Malignant transformation to squamous cell carcinoma (SCC) was noted in 2 patients only. The 3-year outcome resulted in 60 patients with complete response (CR), and this was maintained at the final outcome (last clinic review). Assessment of lesional outcome vs. response showed that 175/178 treated lesions had complete response (CR) at 3-year follow-up, which increased to 176/178 lesions at the last clinic follow-up. CONCLUSION: MAL-PDT offers an effective treatment for AKs lesions with excellent cosmetic outcome.

Type: Article
Title: Photodynamic therapy in the management of actinic keratosis: Retrospective evaluation of outcome
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pdpdt.2016.04.017
Publisher version: http://doi.org/10.1016/j.pdpdt.2016.04.017
Language: English
Additional information: © 2016 Elsevier B.V. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at https://creativecommons.org/licenses/. Access may be initially restricted by the publisher.
Keywords: 5-ALA, MAL, NMSC, PDT, actinic keratosis, photodynamic therapy, pre-cancer, recurrence
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > EDI MaxFac, Diagnostic, Med and Surg Sci
URI: https://discovery.ucl.ac.uk/id/eprint/1500755
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