UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Airway tissue engineering for congenital laryngotracheal disease

Maughan, E; Lesage, F; Butler, CR; Hynds, RE; Hewitt, R; Janes, SM; Deprest, JA; (2016) Airway tissue engineering for congenital laryngotracheal disease. Seminars in Pediatric Surgery , 25 (3) pp. 186-190. 10.1053/j.sempedsurg.2016.02.012. Green open access

[img]
Preview
Text
Maughan_Airway tissue engineering for congenital laryngotracheal disease.pdf

Download (503kB) | Preview

Abstract

Regenerative medicine offers hope of a sustainable solution for severe airway disease by the creation of functional, immunocompatible organ replacements. When considering fetuses and newborns, there is a specific spectrum of airway pathologies that could benefit from cell therapy and tissue engineering applications. While hypoplastic lungs associated with congenital diaphragmatic hernia (CDH) could benefit from cellular based treatments aimed at ameliorating lung function, patients with upper airway obstruction could take advantage from a de novo tissue engineering approach. Moreover, the international acceptance of the EXIT procedure as a means of securing the precarious neonatal airway, together with the advent of fetal surgery as a method of heading off postnatal co-morbidities, offers the revolutionary possibility of extending the clinical indication for tissue-engineered airway transplantation to infants affected by diverse severe congenital laryngotracheal malformations. This article outlines the necessary basic components for regenerative medicine solutions in this potential clinical niche.

Type: Article
Title: Airway tissue engineering for congenital laryngotracheal disease
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1053/j.sempedsurg.2016.02.012
Publisher version: http://dx.doi.org/10.1053/j.sempedsurg.2016.02.012
Language: English
Additional information: Copyright © 2016 Published by Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0
Keywords: Congenital disease, Fetal therapy, Perinatal surgery, Stem cell, Tissue engineering, Trachea, Transplantation
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Development Bio and Cancer Prog
URI: https://discovery.ucl.ac.uk/id/eprint/1499953
Downloads since deposit
121Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item