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Purification of Nanoparticles by Size and Shape

Robertson, JD; Rizzello, L; Avila-Olias, M; Gaitzsch, J; Contini, C; Magoń, MS; Renshaw, SA; (2016) Purification of Nanoparticles by Size and Shape. Scientific Reports , 6 , Article 27494. 10.1038/srep27494. Green open access

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Abstract

Producing monodisperse nanoparticles is essential to ensure consistency in biological experiments and to enable a smooth translation into the clinic. Purification of samples into discrete sizes and shapes may not only improve sample quality, but also provide us with the tools to understand which physical properties of nanoparticles are beneficial for a drug delivery vector. In this study, using polymersomes as a model system, we explore four techniques for purifying pre-formed nanoparticles into discrete fractions based on their size, shape or density. We show that these techniques can successfully separate polymersomes into monodisperse fractions.

Type: Article
Title: Purification of Nanoparticles by Size and Shape
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/srep27494
Publisher version: http://dx.doi.org/10.1038/srep27494
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1499945
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