Safaiyan, S;
Kannaiyan, N;
Snaidero, N;
Brioschi, S;
Biber, K;
Yona, S;
Edinger, AL;
... Simons, M; + view all
(2016)
Age-related myelin degradation burdens the clearance function of microglia during aging.
Nature Neuroscience
, 19
(8)
995-998, [3].
10.1038/nn.4325.
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Safaiyan et al 2016 Age-related myelin degradation burdens the clearance function of microglia during aging.pdf Download (3MB) | Preview |
Abstract
Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.
| Type: | Article |
|---|---|
| Title: | Age-related myelin degradation burdens the clearance function of microglia during aging |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/nn.4325 |
| Publisher version: | http://dx.doi.org/10.1038/nn.4325 |
| Language: | English |
| Additional information: | Copyright © 2016 Nature America, Inc. All rights reserved. |
| Keywords: | Microglia; Myelin biology and repair; Oligodendrocyte |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1499941 |
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