UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Age-related myelin degradation burdens the clearance function of microglia during aging

Safaiyan, S; Kannaiyan, N; Snaidero, N; Brioschi, S; Biber, K; Yona, S; Edinger, AL; ... Simons, M; + view all (2016) Age-related myelin degradation burdens the clearance function of microglia during aging. Nature Neuroscience , 19 (8) 995-998, [3]. 10.1038/nn.4325. Green open access

[img]
Preview
Text
Safaiyan et al 2016 Age-related myelin degradation burdens the clearance function of microglia during aging.pdf

Download (3MB) | Preview

Abstract

Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

Type: Article
Title: Age-related myelin degradation burdens the clearance function of microglia during aging
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nn.4325
Publisher version: http://dx.doi.org/10.1038/nn.4325
Language: English
Additional information: Copyright © 2016 Nature America, Inc. All rights reserved.
Keywords: Microglia; Myelin biology and repair; Oligodendrocyte
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1499941
Downloads since deposit
309Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item