UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

Marques, S; Zeisel, A; Codeluppi, S; van Bruggen, D; Mendanha Falcão, A; Xiao, L; Li, H; ... Castelo-Branco, G; + view all (2016) Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system. Science , 352 (6291) pp. 1326-1329. 10.1126/science.aaf6463. Green open access

[img]
Preview
Text
Richardson-W__Marques et al (Science 2016) with figures.pdf

Download (5MB) | Preview
[img]
Preview
Text
Richardson-W__Supplementary materials Marques et al (Science 2016).pdf

Download (29MB) | Preview

Abstract

Oligodendrocytes have been considered as a functionally homogeneous population in the central nervous system (CNS). We performed single-cell RNA sequencing on 5072 cells of the oligodendrocyte lineage from 10 regions of the mouse juvenile and adult CNS. Thirteen distinct populations were identified, 12 of which represent a continuum from Pdgfra(+) oligodendrocyte precursor cells (OPCs) to distinct mature oligodendrocytes. Initial stages of differentiation were similar across the juvenile CNS, whereas subsets of mature oligodendrocytes were enriched in specific regions in the adult brain. Newly formed oligodendrocytes were detected in the adult CNS and were responsive to complex motor learning. A second Pdgfra(+) population, distinct from OPCs, was found along vessels. Our study reveals the dynamics of oligodendrocyte differentiation and maturation, uncoupling them at a transcriptional level and highlighting oligodendrocyte heterogeneity in the CNS.

Type: Article
Title: Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.aaf6463
Publisher version: http://dx.doi.org/10.1126/science.aaf6463
Language: English
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/1499909
Downloads since deposit
399Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item