Marina, N;
Teschemacher, AG;
Kasparov, S;
Gourine, AV;
(2016)
Glia, sympathetic activity and cardiovascular disease.
Experimental Physiology
, 101
(5)
pp. 565-576.
10.1113/EP085713.
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Abstract
New Findings What is the topic of this review? In this review, we discuss recent findings that provide a novel insight into the mechanisms that link glial cell function with the pathogenesis of cardiovascular disease, including systemic arterial hypertension and chronic heart failure. What advances does it highlight? We discuss how glial cells may influence central presympathetic circuits, leading to maladaptive and detrimental increases in sympathetic activity and contributing to the development and progression of cardiovascular disease. Increased activity of the sympathetic nervous system is associated with the development of cardiovascular disease and may contribute to its progression. Vasomotor and cardiac sympathetic activities are generated by the neuronal circuits located in the hypothalamus and the brainstem. These neuronal networks receive multiple inputs from the periphery and other parts of the CNS and, at a local level, may be influenced by their non-neuronal neighbours, in particular glial cells. In this review, we discuss recent experimental evidence suggesting that astrocytes and microglial cells are able to modulate the activity of sympathoexcitatory neural networks in disparate physiological and pathophysiological conditions. We focus on the chemosensory properties of astrocytes residing in the rostral ventrolateral medulla oblongata and discuss signalling mechanisms leading to glial activation during brain hypoxia and inflammation. Alterations in these mechanisms may lead to heightened activity of sympathoexcitatory CNS circuits and contribute to maladaptive and detrimental increases in sympathetic tone associated with systemic arterial hypertension and chronic heart failure.
| Type: | Article |
|---|---|
| Title: | Glia, sympathetic activity and cardiovascular disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1113/EP085713 |
| Publisher version: | http://dx.doi.org/10.1113/EP085713 |
| Language: | English |
| Additional information: | © 2016 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Physiology, ROSTRAL VENTROLATERAL MEDULLA, SPONTANEOUSLY HYPERTENSIVE-RATS, CENTRAL SLEEP-APNEA, HYPOTHALAMIC NEUROSECRETORY NEURONS, CONGESTIVE-HEART-FAILURE, CENTRAL-NERVOUS-SYSTEM, NECROSIS-FACTOR-ALPHA, NEUROGENIC HYPERTENSION, BRAIN-STEM, MYOCARDIAL-INFARCTION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Education |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1499894 |
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