UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging

Klén, R; Noponen, T; Koikkalainen, J; Lötjönen, J; Thielemans, K; Hoppela, E; Sipilä, H; ... Knuuti, J; + view all (2016) Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging. Nuclear Medicine Communications , 37 (9) pp. 956-968. 10.1097/MNM.0000000000000539. Green open access

[img]
Preview
Text
thielemans_CT-based motion correction_03032016_NMC.pdf

Download (1MB) | Preview

Abstract

BACKGROUND: Dual gating is a method of dividing the data of a cardiac PET scan into smaller bins according to the respiratory motion and the ECG of the patient. It reduces the undesirable motion artefacts in images, but produces several images for interpretation and decreases the quality of single images. By using motion-correction techniques, the motion artefacts in the dual-gated images can be corrected and the images can be combined into a single motion-free image with good statistics. AIM: The aim of the present study is to develop and evaluate motion-correction methods for cardiac PET studies. We have developed and compared two different methods: computed tomography (CT)/PET-based and CT-only methods. METHODS: The methods were implemented and tested with a cardiac phantom and three patient datasets. In both methods, anatomical information of CT images is used to create models for the cardiac motion. RESULTS: In the patient study, the CT-only method reduced motion (measured as the centre of mass of the myocardium) on average 43%, increased the contrast-to-noise ratio on average 6.0% and reduced the target size on average 10%. Slightly better figures (51, 6.9 and 28%) were obtained with the CT/PET-based method. Even better results were obtained in the phantom study for both the CT-only method (57, 68 and 43%) and the CT/PET-based method (61, 74 and 52%). CONCLUSION: We conclude that using anatomical information of CT for motion correction of cardiac PET images, both respiratory and pulsatile motions can be corrected with good accuracy.

Type: Article
Title: Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/MNM.0000000000000539
Publisher version: http://doi.org/10.1097/MNM.0000000000000539
Language: English
Additional information: Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This is a non-final version of an article published in final form in Klén, R; Noponen, T; Koikkalainen, J; Lötjönen, J; Thielemans, K; Hoppela, E; Sipilä, H; (2016) Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging. Nuclear Medicine Communications , 37 (9) pp. 956-968. 10.1097/MNM.0000000000000539.
Keywords: Cardiac positron emission tomography imaging, dual gating, motion correction
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1499760
Downloads since deposit
52Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item