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Statins for hemodialysis patients with diabetes? Long-term follow-up endorses the original conclusions of the 4D Study

Wheeler, DC; Kasiske, BL; (2016) Statins for hemodialysis patients with diabetes? Long-term follow-up endorses the original conclusions of the 4D Study. Kidney International , 89 (6) pp. 1189-1191. 10.1016/j.kint.2016.02.045. Green open access

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Abstract

The clinical benefits of statins in dialysis patients are unproven. New follow-up data from the 4D Study indicate no clear reduction in cardiovascular events among patients with type-2 diabetes. Assessing outcomes 7.4 years beyond the randomization period (20 mg atorvastatin versus placebo), no differences in a composite cardiovascular outcome were observed and no safety concerns emerged. Current Kidney Disease: Improving Global Outcomes (KDIGO) guidelines do not need updating based on these new data.

Type: Article
Title: Statins for hemodialysis patients with diabetes? Long-term follow-up endorses the original conclusions of the 4D Study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.kint.2016.02.045
Publisher version: http://doi.org/10.1016/j.kint.2016.02.045
Language: English
Additional information: Copyright © 2016, International Society of Nephrology. Published by Elsevier Inc. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Science & Technology, Life Sciences & Biomedicine, Urology & Nephrology, LOWERING LDL CHOLESTEROL, CHRONIC KIDNEY-DISEASE, CONTROLLED-TRIAL, METAANALYSIS, SIMVASTATIN, THERAPY
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1498351
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