Wheeler, DC;
Kasiske, BL;
(2016)
Statins for hemodialysis patients with diabetes? Long-term follow-up endorses the original conclusions of the 4D Study.
Kidney International
, 89
(6)
pp. 1189-1191.
10.1016/j.kint.2016.02.045.
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Abstract
The clinical benefits of statins in dialysis patients are unproven. New follow-up data from the 4D Study indicate no clear reduction in cardiovascular events among patients with type-2 diabetes. Assessing outcomes 7.4 years beyond the randomization period (20 mg atorvastatin versus placebo), no differences in a composite cardiovascular outcome were observed and no safety concerns emerged. Current Kidney Disease: Improving Global Outcomes (KDIGO) guidelines do not need updating based on these new data.
| Type: | Article |
|---|---|
| Title: | Statins for hemodialysis patients with diabetes? Long-term follow-up endorses the original conclusions of the 4D Study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.kint.2016.02.045 |
| Publisher version: | http://doi.org/10.1016/j.kint.2016.02.045 |
| Language: | English |
| Additional information: | Copyright © 2016, International Society of Nephrology. Published by Elsevier Inc. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Urology & Nephrology, LOWERING LDL CHOLESTEROL, CHRONIC KIDNEY-DISEASE, CONTROLLED-TRIAL, METAANALYSIS, SIMVASTATIN, THERAPY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1498351 |
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