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Understanding the solid-state hydration behavior of a common amino acid: identification, structural characterization, and hydration/dehydration processes of new hydrate phases of l-lysine

Williams, PA; Hughes, CE; Martin, J; Courvoisier, E; Buanz, ABM; Gaisford, S; Harris, KDM; (2016) Understanding the solid-state hydration behavior of a common amino acid: identification, structural characterization, and hydration/dehydration processes of new hydrate phases of l-lysine. Journal of Physical Chemistry C , 120 (17) pp. 9385-9392. 10.1021/acs.jpcc.5b12420. Green open access

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Abstract

The crystal structure of l-lysine was reported very recently and represented the final member of the set of 20 directly encoded proteinogenic amino acids to have a crystal structure of the enantiomerically pure form determined. Under ambient conditions, l-lysine has a strong propensity to undergo hydration by incorporation of water into the crystal structure, and dehydration under rigorously dry conditions is required to obtain anhydrous l-lysine. In the present paper, we explore the hydration of l-lysine, which has led to the identification and characterization of a hemihydrate phase and a monohydrate phase. As the hydration processes give rise to microcrystalline powder samples of the hydrate phases, powder X-ray diffraction has been exploited for crystal structure determination of both l-lysine hemihydrate and l-lysine monohydrate. The conditions for interconversion between anhydrous l-lysine and the two hydrate phases have been investigated by dynamic vapor sorption measurements, leading to an understanding of the hydration/dehydration behavior in this system.

Type: Article
Title: Understanding the solid-state hydration behavior of a common amino acid: identification, structural characterization, and hydration/dehydration processes of new hydrate phases of l-lysine
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acs.jpcc.5b12420
Publisher version: http://dx.doi.org/10.1021/acs.jpcc.5b12420
Language: English
Additional information: Copyright © 2016 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Physical Chemistry C after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.jpcc.5b12420
Keywords: Powder X-ray diffraction, dynamic vapour sorption, crystal forms, solid-state transformations
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/1497099
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