Williams, PA;
Hughes, CE;
Martin, J;
Courvoisier, E;
Buanz, ABM;
Gaisford, S;
Harris, KDM;
(2016)
Understanding the solid-state hydration behavior of a common amino acid: identification, structural characterization, and hydration/dehydration processes of new hydrate phases of l-lysine.
Journal of Physical Chemistry C
, 120
(17)
pp. 9385-9392.
10.1021/acs.jpcc.5b12420.
Preview |
Text
Williams et al 2016 Identification and Crystal Structure Determination of New Hydrate Phases .pdf Download (1MB) | Preview |
Abstract
The crystal structure of l-lysine was reported very recently and represented the final member of the set of 20 directly encoded proteinogenic amino acids to have a crystal structure of the enantiomerically pure form determined. Under ambient conditions, l-lysine has a strong propensity to undergo hydration by incorporation of water into the crystal structure, and dehydration under rigorously dry conditions is required to obtain anhydrous l-lysine. In the present paper, we explore the hydration of l-lysine, which has led to the identification and characterization of a hemihydrate phase and a monohydrate phase. As the hydration processes give rise to microcrystalline powder samples of the hydrate phases, powder X-ray diffraction has been exploited for crystal structure determination of both l-lysine hemihydrate and l-lysine monohydrate. The conditions for interconversion between anhydrous l-lysine and the two hydrate phases have been investigated by dynamic vapor sorption measurements, leading to an understanding of the hydration/dehydration behavior in this system.
| Type: | Article |
|---|---|
| Title: | Understanding the solid-state hydration behavior of a common amino acid: identification, structural characterization, and hydration/dehydration processes of new hydrate phases of l-lysine |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.jpcc.5b12420 |
| Publisher version: | http://dx.doi.org/10.1021/acs.jpcc.5b12420 |
| Language: | English |
| Additional information: | Copyright © 2016 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Physical Chemistry C after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.jpcc.5b12420 |
| Keywords: | Powder X-ray diffraction, dynamic vapour sorption, crystal forms, solid-state transformations |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1497099 |
Archive Staff Only
 |
View Item |
