UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Tight junctions as regulators of tissue remodelling

Balda, MS; Matter, K; (2016) Tight junctions as regulators of tissue remodelling. Current Opinion in Cell Biology , 42 pp. 94-101. 10.1016/j.ceb.2016.05.006. Green open access

[thumbnail of Balda and Matter Tight junctions as regulators of tissue remodelling.pdf]
Preview
Text
Balda and Matter Tight junctions as regulators of tissue remodelling.pdf

Download (2MB) | Preview

Abstract

Formation of tissue barriers by epithelial and endothelial cells requires neighbouring cells to interact via intercellular junctions, which includes tight junctions. Tight junctions form a semipermeable paracellular diffusion barrier and act as signalling hubs that guide cell behaviour and differentiation. Components of tight junctions are also expressed in cell types not forming tight junctions, such as cardiomyocytes, where they associate with facia adherens and/or gap junctions. This review will focus on tight junction proteins and their importance in tissue homeostasis and remodelling with a particular emphasis on what we have learned from animal models and human diseases.

Type: Article
Title: Tight junctions as regulators of tissue remodelling
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceb.2016.05.006
Publisher version: http://dx.doi.org/10.1016/j.ceb.2016.05.006
Language: English
Additional information: Copyright © 2016 Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1496323
Downloads since deposit
277Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item