Gaitzsch, J;
Delahaye, M;
Poma, A;
Du Prez, F;
Battaglia, G;
(2016)
Comparison of metal free polymer-dye conjugation strategies in protic solvents.
Polymer Chemistry
, 7
(17)
pp. 3046-3055.
10.1039/c6py00518g.
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Abstract
Polymer–dye conjugations are one of the common examples for polymer modifications. They represent a crucial step for imaging in optical microscopy or for tracing and marking macromolecules. In this work, we present a comparison between quick and efficient conjugation reactions that do not rely on the use of a metal catalyst, which could contaminate the resulting polymer and hinder its use for subsequent biological applications. Moreover, since the conjugation strategy needs to be compatible with the solvent system used to solubilise the polymer, we focussed our attention on assessing these conjugation approaches for their feasibility with a sample polymer that is only soluble in protic solvents. The methods studied include the ring-strain promoted azide–alkyne click reaction, thiol/maleimide conjugation as well as the 1,2,4-triazoline-3,5-dione (TAD) with a diene moiety, one of the latest click chemistries available.
| Type: | Article |
|---|---|
| Title: | Comparison of metal free polymer-dye conjugation strategies in protic solvents |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c6py00518g |
| Publisher version: | http://doi.org/10.1039/c6py00518g |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Physical Sciences, Polymer Science, CLICK CHEMISTRY, DELIVERY, PH, FUNCTIONALIZATION, ENCAPSULATION, EFFICIENT, VESICLES, AFFINITY, SYSTEMS, CELLS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1496221 |
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