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BA 4p BOLD response profile distinguishes low and high MS morbidity

Alahmadi, A; Pardini, M; Samson, R; D'Angelo, E; Friston, K; Toosy, A; Wheeler-kingshott, C; (2016) BA 4p BOLD response profile distinguishes low and high MS morbidity. In: Proceedings of the 24th Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM). International Society for Magnetic Resonance in Medicine (ISMRM): Singapore. Green open access

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Abstract

This study investigates how multiple sclerosis (MS) selectively affects regional BOLD response to variable grip forces (GF). It is known that the anterior and posterior BA4 areas are anatomically and functionally distinguishable – and that in healthy subjects there are linear and non-linear BOLD response components. After modelling BOLD responses with a polynomial expansion of the applied GF during task, we showed that in BA4a MS subjects respond like healthy subjects. BOLD response in BA4p, instead, was altered in MS, with those with greatest disability showing the greatest deviations from the non-linear profile of the healthy response.

Type: Proceedings paper
Title: BA 4p BOLD response profile distinguishes low and high MS morbidity
Event: 24th Annual Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM)
Location: Singapore
Dates: 07 May 2016 - 13 May 2016
Open access status: An open access version is available from UCL Discovery
Publisher version: http://dev.ismrm.org/2016/4060.html
Language: English
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1496057
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