Zakharova, LY;
Vasilieva, EA;
Gaynanova, GA;
Mirgorodskaya, AB;
Ibragimova, AR;
Salnikov, VV;
Uchegbu, IF;
... Zuev, YF; + view all
(2015)
The polyacrylic acid/modified chitosan capsules with tunable release of small hydrophobic probe and drug.
Colloids and Surfaces A: Physicochemical and Engineering Aspects
, 471
pp. 93-100.
10.1016/j.colsurfa.2015.02.016.
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Abstract
Nanocapsules (≤200 nm) with a protection effect toward small hydrophobic guests (p-nitrophenyl laurate and acetylsalicylic acid, aspirin) and a tunable sustained release behavior have been fabricated through the layer-by-layer deposition of polyacrylic acid and modified chitosan. Cationic surfactant, cetyltrimethylammonium bromide, was used to increase the affinity of polyelectrolyte to the substrate. The release profile was monitored through original protocol involving a fast cleavage of the substrate released and a spectrophotometric control of the product. The shell permeability of the capsules and hence their protective effect may be tuned through the variation of the number of layers deposited, the sonication, and the adjustment of solution pH. Importantly, the dispersed loads serving as a template for the capsule fabrication may control their properties, including shell permeability.
| Type: | Article |
|---|---|
| Title: | The polyacrylic acid/modified chitosan capsules with tunable release of small hydrophobic probe and drug |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.colsurfa.2015.02.016 |
| Publisher version: | http://dx.doi.org/10.1016/j.colsurfa.2015.02.016 |
| Language: | English |
| Additional information: | Copyright © 2015. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. |
| Keywords: | Layer-by-layer, Polyelectrolyte, Sustained release, Small drug |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1495945 |
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