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Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome

Whitaker, KJ; Vértes, PE; Romero-Garcia, R; Váša, F; Moutoussis, M; Prabhu, G; Weiskopf, N; ... NSPN Consortium, .; + view all (2016) Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome. Proceedings of the National Academy of Sciences of the United States of America , 113 (32) pp. 9105-9110. 10.1073/pnas.1601745113. Green open access

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Abstract

How does human brain structure mature during adolescence? We used MRI to measure cortical thickness and intracortical myelination in 297 population volunteers aged 14-24 y old. We found and replicated that association cortical areas were thicker and less myelinated than primary cortical areas at 14 y. However, association cortex had faster rates of shrinkage and myelination over the course of adolescence. Age-related increases in cortical myelination were maximized approximately at the internal layer of projection neurons. Adolescent cortical myelination and shrinkage were coupled and specifically associated with a dorsoventrally patterned gene expression profile enriched for synaptic, oligodendroglial- and schizophrenia-related genes. Topologically efficient and biologically expensive hubs of the brain anatomical network had greater rates of shrinkage/myelination and were associated with overexpression of the same transcriptional profile as cortical consolidation. We conclude that normative human brain maturation involves a genetically patterned process of consolidating anatomical network hubs. We argue that developmental variation of this consolidation process may be relevant both to normal cognitive and behavioral changes and the high incidence of schizophrenia during human brain adolescence.

Type: Article
Title: Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome
Open access status: An open access version is available from UCL Discovery
DOI: 10.1073/pnas.1601745113
Publisher version: http://dx.doi.org/10.1073/pnas.1601745113
Language: English
Additional information: Copyright © 2016 National Academy of Sciences. This is the accepted manuscript version of this article; the final published version can be found on the PNAS website at http://dx.doi.org/10.1073/pnas.1601745113
Keywords: graph theory, magnetization transfer, microarray, myelinogenesis, partial least squares
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1495906
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