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Orbital mass secondary to infantile acute lymphoblastic leukaemia

Hossain, IT; Moosajee, M; Abou-Rayyah, Y; Pavasovic, V; (2016) Orbital mass secondary to infantile acute lymphoblastic leukaemia. BMJ Case Reports 10.1136/bcr-2016-214872. Green open access

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Abstract

An 8-month-old Asian infant girl was referred with a 1-week history of left periorbital swelling on a background of a narrowed left palpebral aperture over the preceding 8 weeks. There was no history of chronic illness, fever or other systemic features. Examination revealed a tender and fluctuant medial canthal swelling with associated periorbital haematoma. There were no other ophthalmic findings and neurological examination was normal. A MRI scan of the brain and orbit demonstrated abnormal soft tissue with features of an aggressive tumour in the left orbital region with no globe invasion. Peripheral blood smear revealed blast cells, confirmed by bone marrow aspirate. A diagnosis of infant acute lymphoblastic leukaemia was made. The patient was started on risk-stratified chemotherapy according to the Interfant-06 Protocol The periorbital swelling resolved by day eight following a course of prednisolone, the patient continues on chemotherapy and is currently in molecular remission.

Type: Article
Title: Orbital mass secondary to infantile acute lymphoblastic leukaemia
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bcr-2016-214872
Publisher version: http://dx.doi.org/10.1136/bcr-2016-214872
Language: English
Additional information: Copyright © 2016 BMJ Publishing Group. All rights reserved. This article has been accepted for publication in BMJ Case Reports following peer review. The definitive copyedited, typeset version is available online at http://casereports.bmj.com
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1495371
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