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A fully dynamic multi-compartmental poroelastic system: Application to aqueductal stenosis

Chou, D; Vardakis, JC; Guo, L; Tully, BJ; Ventikos, Y; (2016) A fully dynamic multi-compartmental poroelastic system: Application to aqueductal stenosis. Journal of Biomechanics , 49 (11) pp. 2306-2312. 10.1016/j.jbiomech.2015.11.025. Green open access

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Abstract

This study proposes the implementation of a fully dynamic four-network poroelastic model which is underpinned by multiple-network poroelastic theory (MPET), in order to account for the effects of varying stages of aqueductal stenosis and atresia during acute hydrocephalus. The innovation of the fully dynamic MPET implementation is that it avoids the commonplace assumption of quasi-steady behaviour; instead, it incorporates all transient terms in the casting of the equations and in the numerical solution of the resulting discrete system. It was observed that the application of mild stenosis allows for a constant value of amalgamated ventricular displacement in under 2.4 h, whereas the application of a severe stenosis delays this settlement to approximately 10 h. A completely blocked aqueduct does not show a clear sign of reaching a steady ventricular displacement after 24 h. The increasing ventricular pressure (complemented with ventriculomegaly) during severe stenosis is causing the trans-parenchymal tissue region to respond, and this coping mechanism is most attenuated at the regions closest to the skull and the ventricles. After 9 h, the parenchymal tissue shows to be coping well with the additional pressure burden, since both ventriculomegaly and ventricular CSF (cerebrospinal fluid) pressure show small increases between 9 and 24 h. Localised swelling in the periventricular region could also be observed through CSF fluid content, whilst dilation results showed stretch and compression of cortical tissue adjacent to the ventricles and skull.

Type: Article
Title: A fully dynamic multi-compartmental poroelastic system: Application to aqueductal stenosis
Location: Albufeira, PORTUGAL
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jbiomech.2015.11.025
Publisher version: https://doi.org/10.1016/j.jbiomech.2015.11.025
Language: English
Additional information: © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Multiple-network poroelastic theory, Hydrocephalus, Aqueduct, Cerebrospinal fluid, Stenosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1495211
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