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Can physical exercise in old age improve memory and hippocampal function?

Duzel, E; van Praag, H; Sendtner, M; (2016) Can physical exercise in old age improve memory and hippocampal function? Brain , 139 (3) pp. 662-673. 10.1093/brain/awv407. Green open access

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Abstract

Physical exercise can convey a protective effect against cognitive decline in ageing and Alzheimer’s disease. While the long-term health-promoting and protective effects of exercise are encouraging, it’s potential to induce neuronal and vascular plasticity in the ageing brain is still poorly understood. It remains unclear whether exercise slows the trajectory of normal ageing by modifying vascular and metabolic risk factors and/or consistently boosts brain function by inducing structural and neurochemical changes in the hippocampus and related medial temporal lobe circuitry—brain areas that are important for learning and memory. Hence, it remains to be established to what extent exercise interventions in old age can improve brain plasticity above and beyond preservation of function. Existing data suggest that exercise trials aiming for improvement and preservation may require different outcome measures and that the balance between the two may depend on exercise intensity and duration, the presence of preclinical Alzheimer’s disease pathology, vascular and metabolic risk factors and genetic variability.

Type: Article
Title: Can physical exercise in old age improve memory and hippocampal function?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/brain/awv407
Publisher version: http://dx.doi.org/10.1093/brain/awv407
Language: English
Additional information: The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, hippocampus, exercise, cerebral blood flow, Alzheimer's disease, memory, GROWTH-FACTOR-I, ADULT DENTATE GYRUS, SPORADIC ALZHEIMERS-DISEASE, RANDOMIZED-CONTROLLED-TRIAL, MILD COGNITIVE IMPAIRMENT, MEDIAL TEMPORAL-LOBE, A-BETA OLIGOMERS, BODY-MASS INDEX, PATTERN SEPARATION, AEROBIC EXERCISE
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/1494852
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