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Dissociations in Coherence Sensitivity Reveal Atypical Development of Cortical Visual Processing in Congenital Achromatopsia

Burton, E; Wattam-Bell, J; Rubin, GS; Aboshiha, J; Michaelides, M; Atkinson, J; Braddick, O; (2016) Dissociations in Coherence Sensitivity Reveal Atypical Development of Cortical Visual Processing in Congenital Achromatopsia. Investigative Ophthalmology & Visual Science , 57 (4) pp. 2251-2259. 10.1167/iovs.15-18414. Green open access

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Abstract

Purpose: While basic visual functions have been described in subjects with congenital achromatopsia (ACHM), little is known about their mid- or high-level cortical visual processing. We compared midlevel cortical visual processing in ACHM subjects (n = 11) and controls (n = 20). Methods: Abilities to detect global form, global motion, and biological motion embedded in noise were tested across a range of light levels, including scotopic, in which both ACHM subjects and controls must rely on rods. Contrast sensitivity functions (CSFs) were also measured. Results: Achromatopsia subjects showed differential impairments across tests. In scotopic conditions, global form was most impaired, while biological motion was normal. In a subset of three ACHM subjects with normal scotopic CSFs, two of the three showed global form perception worse than controls; all showed global motion comparable to controls; and strikingly, two of the three showed biological motion perception superior to controls. Conclusions: The cone signal appears to play a crucial role in the development of perception of global form, as in ACHM this is impaired even in scotopic conditions, in which controls also have to rely on rods, and even in ACHM subjects with no scotopic spatial vision loss. In contrast, the rod signal appears sufficient for the development of normal (or even superior) extrastriate biological motion perception. These results suggest that ACHM leads to atypical development of cortical vision, highlighting the need to better understand the potential for further reorganization of cortical visual processing following new therapies aimed at restoring cone function.

Type: Article
Title: Dissociations in Coherence Sensitivity Reveal Atypical Development of Cortical Visual Processing in Congenital Achromatopsia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1167/iovs.15-18414
Publisher version: http://dx.doi.org/10.1167/iovs.15-18414
Language: English
Additional information: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Keywords: Science & Technology, Life Sciences & Biomedicine, Ophthalmology, motion perception, form perception, psychophysics, biological motion, rod vision, DORSAL-STREAM VULNERABILITY, HUMAN ROD VISION, LOW-LIGHT LEVELS, BIOLOGICAL MOTION, GLOBAL FORM, GENE-THERAPY, IMAGE DEGRADATION, RETINAL STRUCTURE, PROGRESSIVE LOSS, MACAQUE MONKEYS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1494729
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