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Anatomical features and cell-cell interactions in the human limbal epithelial stem cell niche

Dziasko, MA; Daniels, JT; (2016) Anatomical features and cell-cell interactions in the human limbal epithelial stem cell niche. The Ocular Surface , 14 (3) pp. 322-330. 10.1016/j.jtos.2016.04.002. Green open access

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Abstract

Epithelial stem cells of the ocular surface are essential for the maintenance of corneal transparency and therefore for vision. Human corneal/limbal epithelial stem cells (LESCs) are believed to reside in the limbus, the interface between the peripheral cornea and neighboring conjunctiva. A specific anatomical microenvironment called the niche regulates the proliferative and differentiation potential of LESCs and their daughter cells. This review covers multiple structural and functional aspects of the human limbal epithelial stem cell niche, including: anatomical features of the niche, composition of the local extracellular matrix, soluble factors and signaling pathways, cell-to-cell interactions with surrounding stromal niche cells and melanocytes.

Type: Article
Title: Anatomical features and cell-cell interactions in the human limbal epithelial stem cell niche
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jtos.2016.04.002
Publisher version: http://dx.doi.org/10.1016/j.jtos.2016.04.002
Language: English
Additional information: © 2016 Elsevier Inc. All rights reserved. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher.
Keywords: Cell interactions, cornea, epithelial stem cells, human, limbus, stem cell niche
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1494716
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