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Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed

Patel, S; Penny, CJ; Rahman, T; (2016) Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed. Trends in Biochemical Sciences , 41 (6) pp. 475-477. 10.1016/j.tibs.2016.04.007. Green open access

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Abstract

Two-pore channels (TPCs) are intracellular Ca(2+)-permeable ion channels that are expressed on acidic Ca(2+) stores. They are co-regulated by voltage and Ca(2+) in plant vacuoles and by the second messenger NAADP in animal endo-lysosomes. Two new studies of plant TPC structures reveal essential features of their architecture and provide mechanistic insight into their workings.

Type: Article
Title: Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tibs.2016.04.007
Publisher version: http://dx.doi.org/10.1016/j.tibs.2016.04.007
Language: English
Additional information: © 2016 The Authors. Published by Elsevier Inc. under Creative Commons Attribution (CC BY 4.0)
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1494612
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