Lingam, I;
Avdic-Belltheus, A;
Robertson, NJ;
(2016)
Using animal models to improve care of neonatal encephalopathy.
ADC Education & Practice
, 101
(5)
pp. 271-276.
10.1136/archdischild-2015-309927.
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Abstract
Animal models have become indispensable in the search for novel strategies and therapeutics for effective therapies for neonatal encephalopathy (NE). Over the last 3 decades, the translation of ideas and questions from bedside to bench moved therapeutic hypothermia into the clinic as the first safe and effective therapy for NE. We are now at the stage where animal models are needed to move therapies further forward. We review some of the main animal models in use and discuss advantages and disadvantages of each model, giving a detailed example of a protocol used in a piglet model of NE.
Type: | Article |
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Title: | Using animal models to improve care of neonatal encephalopathy |
Location: | England |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1136/archdischild-2015-309927 |
Publisher version: | http://dx.doi.org/10.1136/archdischild-2015-309927 |
Language: | English |
Additional information: | Copyright © 2016 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health. All rights reserved. This article has been accepted for publication in ADC Education & Practice following peer review. The definitive copyedited, typeset version [Lingam, I; Avdic-Belltheus, A; Robertson, NJ; (2016) Using animal models to improve care of neonatal encephalopathy. ADC Education & Practice, 101 (5) pp. 271-276. 10.1136/archdischild-2015-309927] is available online at: http://dx.doi.org/10.1136/archdischild-2015-309927 |
Keywords: | animal models, neonatal encephalopathy, therapeutic hypothermia |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer |
URI: | https://discovery.ucl.ac.uk/id/eprint/1494608 |
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