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Using animal models to improve care of neonatal encephalopathy

Lingam, I; Avdic-Belltheus, A; Robertson, NJ; (2016) Using animal models to improve care of neonatal encephalopathy. ADC Education & Practice , 101 (5) pp. 271-276. 10.1136/archdischild-2015-309927. Green open access

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Abstract

Animal models have become indispensable in the search for novel strategies and therapeutics for effective therapies for neonatal encephalopathy (NE). Over the last 3 decades, the translation of ideas and questions from bedside to bench moved therapeutic hypothermia into the clinic as the first safe and effective therapy for NE. We are now at the stage where animal models are needed to move therapies further forward. We review some of the main animal models in use and discuss advantages and disadvantages of each model, giving a detailed example of a protocol used in a piglet model of NE.

Type: Article
Title: Using animal models to improve care of neonatal encephalopathy
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/archdischild-2015-309927
Publisher version: http://dx.doi.org/10.1136/archdischild-2015-309927
Language: English
Additional information: Copyright © 2016 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health. All rights reserved. This article has been accepted for publication in ADC Education & Practice following peer review. The definitive copyedited, typeset version [Lingam, I; Avdic-Belltheus, A; Robertson, NJ; (2016) Using animal models to improve care of neonatal encephalopathy. ADC Education & Practice, 101 (5) pp. 271-276. 10.1136/archdischild-2015-309927] is available online at: http://dx.doi.org/10.1136/archdischild-2015-309927
Keywords: animal models, neonatal encephalopathy, therapeutic hypothermia
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer
URI: https://discovery.ucl.ac.uk/id/eprint/1494608
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