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Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease

De Guio, F; Jouvent, E; Biessels, GJ; Black, SE; Brayne, C; Chen, C; Cordonnier, C; ... Chabriat, H; + view all (2016) Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease. Journal of Cerebral Blood Flow and Metabolism , 36 (8) pp. 1319-1337. 10.1177/0271678X16647396. Green open access

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Abstract

Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.

Type: Article
Title: Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0271678X16647396
Publisher version: http://doi.org/10.1177/0271678X16647396
Language: English
Additional information: © Author(s) 2016.
Keywords: Magnetic resonance imaging, atrophy, brain volume, cerebral small vessel disease, lacunes, marker, microbleeds, perivascular spaces, repeatability, reproducibility, variability, white matter hyperintensities
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/1494564
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