Gee, B;
Hodgekins, J;
Fowler, D;
Marshall, M;
Everard, L;
Lester, H;
Jones, PB;
... Birchwood, M; + view all
(2016)
The course of negative symptom in first episode psychosis and the relationship with social recovery.
Schizophrenia Research
, 174
(1-3)
pp. 165-171.
10.1016/j.schres.2016.04.017.
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Abstract
Aims To investigate trajectories of negative symptoms during the first 12 months of treatment for first episode psychosis (FEP), their predictors and relationship to social recovery. Method 1006 participants were followed up for 12 months following acceptance into Early Intervention in Psychosis services. Negative symptom trajectories were modelled using latent class growth analysis (LCGA) and predictors of trajectories examined using multinomial regression. Social recovery trajectories – also modelled using LCGA – of members of each negative symptom trajectory were ascertained and the relationship between negative symptom and social recovery trajectories examined. Results Four negative symptom trajectories were identified: Minimal Decreasing (63.9%), Mild Stable (13.5%), High Decreasing (17.1%) and High Stable (5.4%). Male gender and family history of non-affective psychosis predicted stably high negative symptoms. Poor premorbid adolescent adjustment, family history of non-affective psychosis and baseline depression predicted initially high but decreasing negative symptoms. Members of the Mild Stable, High Stable and High Decreasing classes were more likely to experience stably low functioning than the Minimal Decreasing class. Conclusions Distinct negative symptom trajectories are evident in FEP. Only a small subgroup present with persistently high levels of negative symptoms. A substantial proportion of FEP patients with elevated negative symptoms at baseline will achieve remission of these symptoms within 12 months. However, elevated negative symptoms at baseline, whether or not they remit, are associated with poor social recovery, suggesting targeted interventions for service users with elevated baseline negative symptoms may help improve functional outcomes.
| Type: | Article |
|---|---|
| Title: | The course of negative symptom in first episode psychosis and the relationship with social recovery |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.schres.2016.04.017 |
| Publisher version: | http://doi.org/10.1016/j.schres.2016.04.017 |
| Language: | English |
| Additional information: | Copyright © 2017 Elsevier Ltd. All rights reserved. This is an Open Access article made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher. |
| Keywords: | Negative symptoms; Early intervention; Functioning; Recovery; Longitudinal |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > Comprehensive CTU at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1494359 |
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