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Cortical folding of the preterm brain : a longitudinal analysis of extremely preterm born neonates using spectral matching

Orasanu, ET; Melbourne, A; Cardoso, MJ; Lomabert, H; Kendall, GS; Robertson, NJ; Marlow, N; (2016) Cortical folding of the preterm brain : a longitudinal analysis of extremely preterm born neonates using spectral matching. Brain and Behavior , 6 (8) , Article e00488. 10.1002/brb3.488. Green open access

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Abstract

Introduction: Infants born extremely preterm (<28 weeks of gestation) are at risk of significant neurodevelopmental sequelae. In these infants birth coincides with a period of rapid brain growth and development, when the brain is also vulnerable to a range of insults. Mapping these changes is crucial for identifying potential biomarkers to predict early impairment. Methods: In this study we use surface-based spectral matching techniques to find an intrasubject longitudinal surface correspondence between the white–grey matter boundary at 30 and 40 weeks equivalent gestational age in nine extremely preterm born infants. Results: Using the resulting surface correspondence, we identified regions that undergo more cortical folding of the white–grey matter boundary during the preterm period by looking at changes in well-known curvature measures. We performed Hotelling T2 statistics to evaluate the significance of our findings. Discussion: The prefrontal and temporal lobes exhibit most development during the preterm period, especially in the left hemisphere. Such correspondences are a promising result as longitudinal measurements of change in cortical folding could provide insightful information about the mechanical properties of the underlying tissue and may be useful in inferring changes during growth and development in this vulnerable period.

Type: Article
Title: Cortical folding of the preterm brain : a longitudinal analysis of extremely preterm born neonates using spectral matching
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/brb3.488
Publisher version: http://dx.doi.org/10.1002/brb3.488
Language: English
Additional information: Copyright © 2016 The Authors. Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Cortex; development; registration; shape analysis; spectra
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1493824
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