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Secondary Progressive Multiple Sclerosis: Definition and Measurement

Plantone, D; De Angelis, F; Doshi, A; Chataway, J; (2016) Secondary Progressive Multiple Sclerosis: Definition and Measurement. CNS Drugs , 30 (6) pp. 517-526. 10.1007/s40263-016-0340-9. Green open access

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Abstract

Secondary progressive multiple sclerosis (SPMS) is diagnosed retrospectively and involves a clinical course characterized by a progressive accumulation of neurological disability, independent of relapses, following an initial relapsing–remitting (RR) phase. Our incomplete understanding of the pathological mechanisms underlying neurodegeneration in multiple sclerosis (MS) may explain why, to date, there is no definitive imaging or laboratory test that is able to inform us when the disease is clearly entering into a progressive phase and why the vast majority of clinical trials testing immunosuppressant and immunomodulating drugs in SPMS patients has so far yielded disappointing or mixed results. Here we discuss the definition(s) of SPMS and how it may vary, outcome measurements (current and emerging) and modern trial design.

Type: Article
Title: Secondary Progressive Multiple Sclerosis: Definition and Measurement
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s40263-016-0340-9
Publisher version: http://dx.doi.org/10.1007/s40263-016-0340-9
Language: English
Additional information: Copyright © Springer International Publishing Switzerland 2016. The final publication is available at Springer via http://dx.doi.org/10.1007/s40263-016-0340-9.
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Pharmacology & Pharmacy, Psychiatry, Neurosciences & Neurology, Gray-matter atrophy, Quality-of-life, Clinically Isolated Syndromes, Central-nervous-system, B-cell Follicles, Functional Composite, Brain Atrophy, White-matter, Cognitive Impairment, Outcome Measure
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1493782
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