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Network science for the identification of novel therapeutic targets in epilepsy.

Scott, RC; (2016) Network science for the identification of novel therapeutic targets in epilepsy. F1000Res , 5 , Article 893. 10.12688/f1000research.8214.1. Green open access

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Abstract

The quality of life of children with epilepsy is a function of seizures and associated cognitive and behavioral comorbidities. Current treatments are not successful at stopping seizures in approximately 30% of patients despite the introduction of multiple new antiepileptic drugs over the last decade. In addition, modification of seizures has only a modest impact on the comorbidities. Therefore, novel approaches to identify therapeutic targets that improve seizures and comorbidities are urgently required. The potential of network science as applied to genetic, local neural network, and global brain data is reviewed. Several examples of possible new therapeutic approaches defined using novel network tools are highlighted. Further study to translate the findings into clinical practice is now required.

Type: Article
Title: Network science for the identification of novel therapeutic targets in epilepsy.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.12688/f1000research.8214.1
Publisher version: http://dx.doi.org/10.12688/f1000research.8214.1
Language: English
Additional information: © 2016 Scott RC. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Epilepsy, network science, therapeutic targets
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1493680
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