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Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study

Siebald, C; Khandaker, GM; Zammit, S; Lewis, G; Jones, PB; (2016) Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study. Comprehensive Psychiatry , 69 pp. 45-52. 10.1016/j.comppsych.2016.05.004. Green open access

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Abstract

Background: Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and subsequent adolescent PEs in the population-based prospective ALSPAC birth cohort. / Method: Depression, anxiety, attention deficit hyperactivity disorder, oppositional defiant or conduct disorder, and pervasive developmental disorder were diagnosed according to DSM-IV criteria in 8253 participants at age 8 years. IQ was assessed by WISC-III also at 8 years. PEs, depressive and anxiety symptoms were assessed at 13 years. Logistic regression calculated odds ratio (OR) for PEs at 13 years associated with psychiatric disorders at 8 years. Linear regression calculated mean difference in IQ between groups with and without psychiatric disorder. Mediating effects of IQ, mood and anxiety symptoms on the psychiatric disorder-PEs relationship were examined. / Results: In total, 599 children were assessed to have a DSM-IV psychiatric disorder at 8 years (7.2%). These children compared with those without any psychiatric disorder performed worse on all measures of IQ; adjusted mean difference in total IQ − 6.17 (95% CI, − 7.86, − 4.48). Childhood psychiatric disorders were associated with PEs subsequently in adolescence; adjusted OR 1.96 (95% CI, 1.47–2.68). The association between psychiatric disorder and subsequent PEs was partly mediated by, independently, IQ deficit at 8 years and depressive and anxiety symptoms at 13 years. / Conclusions: The findings indicate that adolescent PEs are associated with general cognitive ability and past and present psychopathological factors.

Type: Article
Title: Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.comppsych.2016.05.004
Publisher version: http://dx.doi.org/10.1016/j.comppsych.2016.05.004
Language: English
Additional information: Copyright © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/1493566
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