Siebald, C;
Khandaker, GM;
Zammit, S;
Lewis, G;
Jones, PB;
(2016)
Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study.
Comprehensive Psychiatry
, 69
pp. 45-52.
10.1016/j.comppsych.2016.05.004.
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Abstract
Background: Adolescent psychotic experiences (PEs) are common, and are associated with both psychotic and non-psychotic illnesses. In order to examine psychopathological and cognitive antecedents of adolescent PEs, we have conducted a longitudinal study of common childhood psychiatric disorders and subsequent adolescent PEs in the population-based prospective ALSPAC birth cohort. / Method: Depression, anxiety, attention deficit hyperactivity disorder, oppositional defiant or conduct disorder, and pervasive developmental disorder were diagnosed according to DSM-IV criteria in 8253 participants at age 8 years. IQ was assessed by WISC-III also at 8 years. PEs, depressive and anxiety symptoms were assessed at 13 years. Logistic regression calculated odds ratio (OR) for PEs at 13 years associated with psychiatric disorders at 8 years. Linear regression calculated mean difference in IQ between groups with and without psychiatric disorder. Mediating effects of IQ, mood and anxiety symptoms on the psychiatric disorder-PEs relationship were examined. / Results: In total, 599 children were assessed to have a DSM-IV psychiatric disorder at 8 years (7.2%). These children compared with those without any psychiatric disorder performed worse on all measures of IQ; adjusted mean difference in total IQ − 6.17 (95% CI, − 7.86, − 4.48). Childhood psychiatric disorders were associated with PEs subsequently in adolescence; adjusted OR 1.96 (95% CI, 1.47–2.68). The association between psychiatric disorder and subsequent PEs was partly mediated by, independently, IQ deficit at 8 years and depressive and anxiety symptoms at 13 years. / Conclusions: The findings indicate that adolescent PEs are associated with general cognitive ability and past and present psychopathological factors.
| Type: | Article |
|---|---|
| Title: | Association between childhood psychiatric disorders and psychotic experiences in adolescence: A population-based longitudinal study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.comppsych.2016.05.004 |
| Publisher version: | http://dx.doi.org/10.1016/j.comppsych.2016.05.004 |
| Language: | English |
| Additional information: | Copyright © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1493566 |
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