Veloudi, P;
Blizzard, L;
Srikanth, VK;
McCartney, P;
Lukoshkova, EV;
Hughes, AD;
Head, GA;
(2016)
Associations of blood pressure variability and retinal arteriolar diameter in participants with type 2 diabetes.
Diabetes and Vascular Disease Research
, 13
(4)
pp. 299-302.
10.1177/1479164116633424.
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Abstract
Blood pressure variability is associated with macrovascular complications and stroke, but its association with the microcirculation in type II diabetes has not been assessed. This study aimed to determine the relationship between blood pressure variability indices and retinal arteriolar diameter in non-diabetic and type II diabetes participants. Digitized retinal images were analysed to quantify arteriolar diameters in 35 non-diabetic (aged 52 ± 11 years; 49% male) and 28 type II diabetes (aged 61 ± 9 years; 50% male) participants. Blood pressure variability was derived from 24-h ambulatory blood pressure. Arteriolar diameter was positively associated with daytime rate of systolic blood pressure variation (p = 0.04) among type II diabetes participants and negatively among non-diabetics (p = 0.008; interaction p = 0.001). This finding was maintained after adjusting for age, sex, body mass index and mean daytime systolic blood pressure. These findings suggest that the blood pressure variability-related mechanisms underlying retinal vascular disease may differ between people with and without type II diabetes.
| Type: | Article |
|---|---|
| Title: | Associations of blood pressure variability and retinal arteriolar diameter in participants with type 2 diabetes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1177/1479164116633424 |
| Publisher version: | http://dx.doi.org/10.1177/1479164116633424 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2016. Published by Sage Publications. The published version of record is available from the journal website at http://dx.doi.org/10.1177/1479164116633424 |
| Keywords: | Blood pressure variability; microcirculation; diabetes; arteriolar diameter |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1493366 |
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