UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Electrospun gelatin nanofibers loaded with vitamins A and E as antibacterial wound dressing materials

Williams, GR; Li, H; Wang, M; Wu, J; Sun, X; Lv, Y; Zhu, LM; (2016) Electrospun gelatin nanofibers loaded with vitamins A and E as antibacterial wound dressing materials. RSC Advances , 55 (6) pp. 50267-50277. 10.1039/C6RA05092A. Green open access

[thumbnail of Heyu RSC Adv accepted MS.pdf]
Preview
Text
Heyu RSC Adv accepted MS.pdf - Accepted Version

Download (8MB) | Preview

Abstract

Vitamin A palmitate and vitamin E TPGS, common derivatives of the unstable vitamins A and E, were successfully incorporated into biodegradable gelatin nanofibers via electrospinning. Electron microscopy showed that smooth cylindrical fibers were produced, albeit with a small amount of beading visible for the vitamin-loaded systems. The diameters of the fibers decrease with the addition of vitamins. The presence of the vitamins in the fibers was confirmed by IR spectroscopy, and X-ray diffraction showed them to exist in the amorphous physical form post-electrospinning. The addition of vitamins did not affect the hydrophilic properties of the gelatin nanofibers. Fibers containing vitamin A or E alone showed a sustained release profile over more than 60 hours, and those incorporating both vitamins showed similar release characteristics, except that the extent of release for vitamin A was increased. Antibacterial tests demonstrated that materials loaded with vitamin E were effective in inhibiting the growth of E. coli and S. aureus. The fibers could promote the proliferation of fibroblasts during the early stages of culture, and enhance the expression of collagen-specific genes. In vivo tests determined that the fibers loaded with vitamins have better wound healing performance than a commercially used antiseptic gauze and casting films.

Type: Article
Title: Electrospun gelatin nanofibers loaded with vitamins A and E as antibacterial wound dressing materials
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/C6RA05092A
Publisher version: http://dx.doi.org/10.1039/C6RA05092A
Language: English
Additional information: This journal is © The Royal Society of Chemistry 2016.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/1493341
Downloads since deposit
235Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item