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No evidence that HIV-1 subtype C infection compromises the efficacy of tenofovir containing regimens: cohort study in the United Kingdom

White, EM; Tostevin, A; Sabin, C; Pillay, D; Dunn, DT; Smit, E; Churchill, D; ... Booth, C; + view all (2016) No evidence that HIV-1 subtype C infection compromises the efficacy of tenofovir containing regimens: cohort study in the United Kingdom. Journal of Infectious Diseases , 214 (9) pp. 1302-1308. 10.1093/infdis/jiw213. Green open access

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Abstract

Concern has been expressed that tenofovir-containing regimens may have reduced effectiveness in the treatment of HIV-1 subtype C infections due to a propensity for these viruses to develop a key tenofovir-associated resistance mutation. We evaluated whether subtype influenced rates of virological failure in a cohort of 8746 patients from the United Kingdom who received a standard tenofovir-containing first-line regimen and were followed for a median of 3.3 years. In unadjusted analyses, the rate of failure was approximately two-fold higher among patients with subtype C virus compared to subtype B (hazard ratio[HR]=1.85,95% CI 1.49-2.33,P<0.001). However, the increased risk was greatly attenuated in analyses adjusting for demographic and clinical factors (adjusted HR=1.15,95% CI 0.83-1.59,P=0.41). There were no differences between subtypes C and non-B/C in either univariate or multivariate analysis. These observations imply there is no intrinsic effect of viral subtype on the efficacy of tenofovir-containing regimens.

Type: Article
Title: No evidence that HIV-1 subtype C infection compromises the efficacy of tenofovir containing regimens: cohort study in the United Kingdom
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/infdis/jiw213
Publisher version: http:/dx.doi.org/10.1093/infdis/jiw213
Language: English
Additional information: © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Tenofovir, HIV-1, subtype, virological failure, K65R
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1493244
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