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Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers

MacDonald, B; Murray, L; Moutsiana, C; Fearon, RMP; Cooper, PJ; Halligan, SL; Johnstone, T; (2016) Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers. Biological Psychology , 118 pp. 147-153. 10.1016/j.biopsycho.2016.05.006. Green open access

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Abstract

Maternal depression is associated with increased risk for offspring mood and anxiety disorders. One possible impact of maternal depression during offspring development is on the emotional autobiographical memory system. We investigated the neural mechanisms of emotional autobiographical memory in adult offspring of mothers with postnatal depression (N = 16) compared to controls (N = 21). During fMRI, recordings of participants describing one pleasant and one unpleasant situation with their mother and with a companion, were used as prompts to re-live the situations. Compared to controls we predicted the PND offspring would show: greater activation in medial and posterior brain regions implicated in autobiographical memory and rumination; and decreased activation in lateral prefrontal cortex and decreased connectivity between lateral prefrontal and posterior regions, reflecting reduced control of autobiographical recall. For negative situations, we found no group differences. For positive situations with their mothers, PND offspring showed higher activation than controls in left lateral prefrontal cortex, right frontal pole, cingulate cortex and precuneus, and lower connectivity of right middle frontal gyrus, left middle temporal gyrus, thalamus and lingual gyrus with the posterior cingulate. Our results are consistent with adult offspring of PND mothers having less efficient prefrontal regulation of personally relevant pleasant autobiographical memories.

Type: Article
Title: Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.biopsycho.2016.05.006
Publisher version: http://dx.doi.org/10.1016/j.biopsycho.2016.05.006
Language: English
Additional information: © 2016 The Author(s). Published by Elsevier B.V. This article (Macdonald, Birthe, Murray, Lynne, Moutsiana, Christina, Fearon, Pasco, Cooper, Peter J, Halligan, Sarah L., Johnstone, Tom, Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers. Biological Psychology http://dx.doi.org/10.1016/j.biopsycho.2016.05.006) is available under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/).
Keywords: Autobiographical memory; postnatal depression; emotion; regulation; prefrontal cortex; development
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/1493138
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