UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Opposing effects of negative emotion on amygdalar and hippocampal memory for items and associations

Bisby, JA; Horner, AJ; Hørlyck, LD; Burgess, N; (2016) Opposing effects of negative emotion on amygdalar and hippocampal memory for items and associations. Social Cognitive and Affective Neuroscience , 11 (6) pp. 981-990. 10.1093/scan/nsw028. Green open access

[thumbnail of Bisby et al 2016 Opposing effects of negative emotion.pdf]
Preview
Text
Bisby et al 2016 Opposing effects of negative emotion.pdf

Download (634kB) | Preview

Abstract

Although negative emotion can strengthen memory of an event it can also result in memory disturbances, as in post-traumatic stress disorder (PTSD). We examined the effects of negative item content on amygdalar and hippocampal function in memory for the items themselves and for the associations between them. During fMRI, we examined encoding and retrieval of paired associates made up of all four combinations of neutral and negative images. At test, participants were cued with an image and, if recognised, had to retrieve the associated (target) image. The presence of negative images increased item memory but reduced associative memory. At encoding, subsequent item recognition correlated with amygdala activity, while subsequent associative memory correlated with hippocampal activity. Hippocampal activity was reduced by the presence of negative images, during encoding and correct associative retrieval. In contrast, amygdala activity increased for correctly retrieved negative images, even when cued by a neutral image. Our findings support a dual representation account, whereby negative emotion up-regulates the amygdala to strengthen item memory but down-regulates the hippocampus to weaken associative representations. These results have implications for the development and treatment of clinical disorders in which diminished associations between emotional stimuli and their context contribute to negative symptoms, as in PTSD.

Type: Article
Title: Opposing effects of negative emotion on amygdalar and hippocampal memory for items and associations
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/scan/nsw028
Publisher version: http://dx.doi.org/10.1093/scan/nsw028
Language: English
Additional information: Copyright © The Author (2016). Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited
Keywords: hippocampus; amygdala; item memory; associative memory
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/1492800
Downloads since deposit
102Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item